PCORI To Solicit More Head-To-Head Comparative Studies-thegraysheet: The Patient-Centered Outcomes Research Institute is taking action to boost the number of head-to-head comparative effectiveness trials it funds after a review of applications selected for funding during its first three cycles found a relatively low number of direct head-to-head comparisons. “It’s pretty clear that PCORI needs to do something to increase in its portfolio the numbers of genuine primary comparative evaluations of prevention, diagnosis and treatment management options,” PCORI Executive Director Joe Selby said during the institute’s Nov. 18 board of governors meeting in Atlanta. So he described a “very early proposal for … a set of actions to address the relative lack of primary head-to-head comparative studies.”